1657014-42-0
中文名稱
1657014-42-0
英文名稱
EOS-62353
CAS
1657014-42-0
分子式
C16H21BrClN5O
分子量
414.73
MOL 文件
1657014-42-0.mol
1657014-42-0 結構式
應用領域
用途一
GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.常見問題列表
概述
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) 是一種選擇性的，可口服的 CHK1 抑制劑，IC50 值為 1.2 nM，具有抗腫瘤活性。