1446194-56-4
中文名稱
硼替佐米雜質(zhì)H
英文名稱
bortezoMib iMpurity H
CAS
1446194-56-4
分子式
C19H24N4O2
分子量
340.42
MOL 文件
1446194-56-4.mol
更新日期
2025/08/05 15:27:05

基本信息
中文別名
硼替佐米雜質(zhì)S硼替佐米雜質(zhì)H
硼替佐米雜質(zhì)05
硼替佐米雜質(zhì) 11
BORTEZOMIBQ雜質(zhì) H
N-[(1S)-2-[(3-甲基丁基)氨基]-2-氧代-1-(苯基甲基)乙基]-2-吡嗪甲酰胺
英文別名
Bortezomib Imp.HBortezomib Impurity S
bortezoMib iMpurity H
(S)-N-(1-(isopentylaMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
2-Pyrazinecarboxamide, N-[(1S)-2-[(3-methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-
Bortezomib impurity 11/(S)-N-(1-(Isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
溶解度Chloroform (Slightly), Dichloromethane (Slightly)
形態(tài)Solid
顏色White to Off-White
InChIInChI=1S/C19H24N4O2/c1-14(2)8-9-22-18(24)16(12-15-6-4-3-5-7-15)23-19(25)17-13-20-10-11-21-17/h3-7,10-11,13-14,16H,8-9,12H2,1-2H3,(H,22,24)(H,23,25)/t16-/m0/s1
InChIKeyUJZOAWFAGJVEGQ-INIZCTEOSA-N
SMILESC1(C(N[C@@H](CC2=CC=CC=C2)C(NCCC(C)C)=O)=O)=NC=CN=C1
應(yīng)用領(lǐng)域
用途一
N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide is an impurity of Bortezomib (B675700) which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.