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1433222-47-9

中文名稱 KISS1R激動劑
英文名稱 TAK-448
CAS 1433222-47-9
分子式 C64H90F3N17O16
分子量 1410.52
MOL 文件 1433222-47-9.mol
1433222-47-9 結(jié)構(gòu)式 1433222-47-9 結(jié)構(gòu)式

應(yīng)用領(lǐng)域

用途一
TAK-448 is an investigational oligopeptide analog of kisspeptin and a potent agonist of the GPR54 receptor. In animals, acute TAK-448 administration stimulates LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. TAK-448 has exhibited potent antitumor activity in rat androgen-dependent prostate cancer models. Therefore, TAK-448 may be useful in the treatment of PC in humans..
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