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1393712-18-9

英文名稱 PF-05139962
CAS 1393712-18-9
分子式 C21H27N5O4S
分子量 445.54
MOL 文件 1393712-18-9.mol
1393712-18-9 結(jié)構(gòu)式 1393712-18-9 結(jié)構(gòu)式

基本信息

英文別名
PF-05139962

應(yīng)用領(lǐng)域

用途一
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.
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