1352011-38-1
中文名稱
化合物 T24758
英文名稱
1-Piperidinecarboxylic acid, 4-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CAS
1352011-38-1
分子式
C16H17ClF6N2O4S
分子量
482.83
MOL 文件
1352011-38-1.mol
1352011-38-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T24758 英文別名
SAR127303SAR-127303
SAR 127303
1-Piperidinecarboxylic acid, 4-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
物理化學(xué)性質(zhì)
沸點463.2±55.0 °C(Predicted)
密度1.466±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)10.93±0.50(Predicted)
應(yīng)用領(lǐng)域
用途一
SAR127303 is a potent covalent MAGL inhibitor. SAR127303 behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice. In vivo, SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain.