AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. It acts by significantly restoring decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively.
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概述
(S)-AS1069562 是 AS1069562 (HY-138257A) 的 S 型異構體。AS1069562 是具有口服活性的 5-HT 和 NE 再攝取抑制劑，IC50 值分別為 0.35 μM 和 3.3 μM。AS1069562 具有鎮(zhèn)痛活性。AS1069562 可通過改善神經(jīng)營養(yǎng)支持來改善神經(jīng)功能損傷。
