1192810-88-0
中文名稱
化合物 T26862
英文名稱
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE
CAS
1192810-88-0
分子式
C18H20N4O
分子量
308.39
MOL 文件
1192810-88-0.mol

基本信息
中文別名
化合物 T26862 英文別名
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE物理化學(xué)性質(zhì)
沸點492.3±55.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)11.06±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients