CM-10-18 is a potent ER α-glucosidase inhibitor. CM-10-18 efficiently protected the lethality of dengue virus infection of mice. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever.
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概述
CM-10-18 在體外和治療動(dòng)物體內(nèi)(口服)都有效的 α-glucosidases I and II 的抑制劑。CM-10-18 能抑制培養(yǎng)的人細(xì)胞感染 DENV,降低小鼠 DENV峰值病毒血癥。