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1143579-78-5

中文名稱 3-(1-(3-([1;1'-BIPHENYL]-4-YLAMINO)-3-OXOPROPYL)-1H-1;2;3-TRIAZOL-4-YL)-6-HYDROXY-1-METHYL-2-PHENYL-1H-INDOLE-5-CARBOXYLIC ACID
英文名稱 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
CAS 1143579-78-5
分子式 C33H27N5O4
分子量 557.599
MOL 文件 1143579-78-5.mol
1143579-78-5 結(jié)構(gòu)式 1143579-78-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27591
英文別名
II-B08
3-(1-(3-([1
FAP1 Inhibitor
CD45 Inhibitor V
LMWPTP Inhibitor
Lyp Inhibitor III
1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1
3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

物理化學(xué)性質(zhì)

密度1.34±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)2.91±0.30(Predicted)

應(yīng)用領(lǐng)域

用途一
II-B08, also known as PTP Inhibitor XXXI, is a cell-permeable SHP2 inhibitor (IC50 = 5.5 μM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation, providing supporting evidence that chemical inhibition of SHP2 may be therapeutically useful for anticancer and antileukemia treatment. X-ray crystallographic analysis of the structure of SHP2 in complex with 9 reveals molecular determinants that can be exploited for the acquisition of more potent and selective SHP2 inhibitors.

常見(jiàn)問(wèn)題列表

概述
II-B08 是一種可逆且非競(jìng)爭(zhēng)性的 SHP2 抑制劑 (對(duì) SHP2、SHP1、PTP1B 的 IC50 分別為 5.5 μM、15.7、14.3 μM)。II-B08 可用于癌癥研究。
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