| Identification | Back Directory | [Name]
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride | [CAS]
98206-09-8 | [Synonyms]
CS-1200
DU 28893
DU-28853 HYDROCHLORIDE
Eltoprazine hydrochloride
(DU-28853 hydrochloride)
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride | [Molecular Formula]
C12H16N2O2.ClH | [MOL File]
98206-09-8.mol | [Molecular Weight]
256.731 |
| Chemical Properties | Back Directory | [Melting point ]
256-258° | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:25.5(Max Conc. mg/mL);99.33(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);116.85(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);97.38(Max Conc. mM)
PBS (pH 7.2):1.0(Max Conc. mg/mL);3.9(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);389.51(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white | [Water Solubility ]
H2O: 10mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
5-HT1 and 5-HT2C receptor partial agonist that has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. A novel drug for the treatment of anxiety as well as other neurological and mental disorders. | [Biological Activity]
Eltoprazine hyrochloride is a serotonin 5-HT1A/1B receptor agonist th at has been shown to reduce L-DOPA-induced dyskinesias in in experimental models of Parkinsonμs Disease and in human patients. It has Ki values for 5-HT1A5-HT1B and 5-HT1C receptors of 40 nM and 52 nMrespectively. | [in vivo]
Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2]. | [IC 50]
5-HT1A Receptor; 5-HT1B Receptor; 5-HT2C Receptor | [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|