| Identification | Back Directory | [Name]
LIPOXIN B4 | [CAS]
98049-69-5 | [Synonyms]
LXB4
LIPOXIN B4
5(S),14(R)-Lipoxin B4
UXVRTOKOJOMENI-WLPVFMORSA-N
5(S), 14(R), 15(S)-TRIHYDROXYEICOSA-6E,8Z,10E,12E-TETRAENOIC ACID
(5S,14R,15S)-5,14,15-Trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoic acid
(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid
(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxy-6,8,10,12-icosatetraenoic acid
6,8,10,12-Eicosatetraenoic acid, 5,14,15-trihydroxy-, (5S,6E,8Z,10E,12E,14R,15S)- | [Molecular Formula]
C20H32O5 | [MDL Number]
MFCD00870250 | [MOL File]
98049-69-5.mol | [Molecular Weight]
352.47 |
| Hazard Information | Back Directory | [Uses]
5(S),14(R)-Lipoxin B4 is a positional isomer of LXA4. | [Uses]
Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M. | [Definition]
ChEBI: Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. It has a role as a human metabolite. It is a lipoxin, a long-chain fatty acid and a hydroxy polyunsaturated fatty acid. It is a conjugate acid of a lipoxin B4(1-). | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
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