| Identification | Back Directory | [Name]
CHLORISONDAMINE DIIODIDE | [CAS]
96750-66-2 | [Synonyms]
Chlorisondamine (iodide)
4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide | [Molecular Formula]
C14Cl4H20I2N2 | [MDL Number]
MFCD01074794 | [MOL File]
96750-66-2.mol | [Molecular Weight]
611.94 |
| Hazard Information | Back Directory | [Description]
Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg. | [Uses]
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
| [Biochem/physiol Actions]
Chlorisondamine diiodide mediates ganglionic and central blockade. | [in vivo]
Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks[1]. | Animal Model: | Rats (treated once with nicotine 0.4 mg/kg, s.c.)[1] | | Dosage: | 0.2, 1.0, 5.0 μg | | Administration: | IV; single dosage | | Result: | Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks. |
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Sigma-Aldrich
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Energy Chemical
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Merck KGaA
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