| Identification | Back Directory | [Name]
L-Lysyl-L-alpha-aspartyl-L-isoleucyl-N5-(aminocarbonyl)-L-ornithinamide | [CAS]
960531-53-7 | [Synonyms]
Trylagen
Decorinyl
Tripeptide-10 citrulline
Tripeptide-10 Citrullinepowder
Decorinyl/Tripeptide-10 citrulline
Tripeptide-10 Citrulline, decorinyl
L-Ornithinamide, L-lysyl-L-α-aspartyl-L-isoleucyl-N5-(aminocarbonyl)-
L-Lysyl-L-alpha-aspartyl-L-isoleucyl-N5-(aminocarbonyl)-L-ornithinamide
(3S)-4-[[(2S,3S)-1-[[(2S)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2,6-diaminohexanoyl]amino]-4-oxobutanoic acid | [EINECS(EC#)]
202-705-0 | [Molecular Formula]
C22H42N8O7 | [MOL File]
960531-53-7.mol | [Molecular Weight]
530.62 |
| Questions And Answer | Back Directory | [Benifits in Skin]
Tripeptide-10
Citrulline, or Decorinyl, is a tetrapeptide engineered in 2008 from decorin, whose peptide chain follows
the +, –, 0, + charge pattern shown to be necessary for the binding of decorin to collagen. Not only
does Tripeptide-10 Citrulline help regulate fibrillogenesis, it also regulates collagen fiber dimensions
and uniformity, making this oligopeptide a good candidate for maintaining elasticity of skin and reducing
wrinkles. A single-blinded parallel group controlled trial compared cream containing Tripeptide-10
Citrulline to placebo. |
| Chemical Properties | Back Directory | [Boiling point ]
965.2±65.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [pka]
4.15±0.10(Predicted) | [InChIKey]
UKVZHOYDLCJTIU-VPRSOUQONA-N | [SMILES]
C(NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)N)(=O)[C@H](CCCNC(N)=O)N |&1:4,5,12,20,28,r| |
| Hazard Information | Back Directory | [Description]
Tripeptide-10 Citrulline (also known under the trade name Decorinyl?) is a brilliant new collagen organizing tetrapeptide that mimics decorin, improving collagen structures and restoring the skin's suppleness and resiliency. Thanks to decorin-like action, it regulates the fibrillogenesis process and collagen fibril dimensions. | [Definition]
Tripeptide-10 Citrulline is a new cosmetic active, designed as a substitute of decorin, that specifically targets collagen fibre organization to regulate collagen fibrillogenesis. | [Biological Functions]
Tripeptide-10 Citrulline ensures uniformity in fibril diameter and increases skin suppleness. Due to its good cohesion of collagen fibres, Tripeptide-10 Citrulline is widely used in anti-aging cosmetic products. | [General Description]
Citrulline is an organic compound and amino acid that is extracted from the skin of the watermelon, among other things. Like all amino acids it has water-binding properties and is therefore used in skin care cosmetics as moisturizer. | [Mechanism of action]
The aging process makes notable changes in the skin proteins. Decorin is an essential protein in the skin that controls collagen aggregation, equalizes fibril diameters, and maintains a normal packing. Unfortunately, the changes also affect decorin that becomes truncated and loses its effectiveness over time. This modified form (non-functional) of decorin, missing in young skin, lacks parts that can interact with collagen. As a result, it leaves a considerable negative effect on the skin's firmness and elasticity, resulting in morphologic changes in collagen organization in the mature skin. |
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