| Identification | Back Directory | [Name]
BI605906 | [CAS]
960293-88-3 | [Synonyms]
CS-2032
BI605906
3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide
3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]- | [Molecular Formula]
C17H22F2N4O3S2 | [MDL Number]
MFCD22665698 | [MOL File]
960293-88-3.mol | [Molecular Weight]
432.51 |
| Chemical Properties | Back Directory | [Boiling point ]
713.7±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: 1 mg/ml; DMSO: 30 mg/ml | [form ]
A crystalline solid | [pka]
16.18±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BI 605906, is a novel inhibitors of the kappa B kinase subunit β (IKKβ; IC50 = 380 nM). | [Biological Activity]
BI605906 is a selectiveATP-competitive IKB kinase β (IKK2IKKβIKK-beta) inhibitor (IC50 = 380 nM[ATP] = 0.1 mM) with no potency toward 100 other kinasesincluding IKKαIKKεTBK1and IGF1R (IC50 ≥7.6 μM). BI605906 (10 μM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction. | [IC 50]
IKKβ: 380 nM (IC50, at 0.1 mM ATP) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|