| Identification | Back Directory | [Name]
Eflornithine hydrochloride hydrate | [CAS]
96020-91-6 | [Synonyms]
Vaniqa
Unii-4nh22ndw9h
DFMO EFLORNITHINE
Eflornithine HCl API
Eflornithine HCl hydrate
DMFO HCl/Eflornithine HCl
Eflornithine HCl Monohydrate
MDL-71782 hydrochloride hydrate
RMI-71782 hydrochloride hydrate
Eflornithine hydrochloride salt
Eflornithine hydrochloride hydrate
Eflornithine hydrochloride 1-hydrate
H-α-Difluoro-Me-DL-Orn-OH · HCl · H?O
H-a-Difluoro-Me-DL-Orn-OH · HCl · H2O
Eflornithine hydrochloride monohydrate
EflornithineHydrochlorideMonohydrate>
H-alpha-Difluoro-Me-DL-Orn-OH . HCl . H2O
2,5-diamino-2-(difluoromethyl)pentanoic acid
eflornithine,Eflornithinehydrochloridehydrate
α-difluoromethylornithine hydrochloride hydrate
2-(Difluoromethyl)ornithine hydrochloride hydrate
DL-α-Difluoromethylornithine (hydrochloride hydrate)
DL-α-DifluoromethylornithineHydrochlorideMonohydrate
DL-α-Difluoromethylornithine Hydrochloride Monohydrate
Ornithine,2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1)
DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem
DFMO · HCl · H2O, Eflornithine · HCl · H2O, a-DifluoroMethylornithine · HCl · H2O | [Molecular Formula]
C6H12F2N2O2 | [MDL Number]
MFCD00242734 | [MOL File]
96020-91-6.mol | [Molecular Weight]
236.65 |
| Chemical Properties | Back Directory | [Melting point ]
>210°C (dec.) | [storage temp. ]
-20°C Freezer | [solubility ]
Soluble in Water (up to 25 mg/ml). | [form ]
White powder | [color ]
White | [Water Solubility ]
water: 1mg/mL
methanol: 25mg/mL | [Merck ]
14,3522 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. | [CAS DataBase Reference]
96020-91-6 |
| Hazard Information | Back Directory | [Description]
Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo. | [Chemical Properties]
White Solid | [Uses]
Eflornithine hydrochloride hydrate is an Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis.It is used in the treatment of hirsutism.
| [Definition]
ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine. | [Brand name]
Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica). | [General Description]
A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro. | [Biological Activity]
Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor. | [Biochem/physiol Actions]
Primary TargetODC | [storage]
Store at -20°C | [References]
1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195
2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243
3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945 |
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