| Identification | Back Directory | [Name]
VK-II-86 | [CAS]
955371-84-3 | [Synonyms]
VK-II-86
4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol
2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]- | [Molecular Formula]
C25H28N2O4 | [MDL Number]
MFCD29770802 | [MOL File]
955371-84-3.mol | [Molecular Weight]
420.5 |
| Chemical Properties | Back Directory | [Boiling point ]
660.6±55.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Soluble | [form ]
A solid | [pka]
14.43±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1]. | [in vivo]
VK-II-86 markedly reduces the number of non-sustained and sustained ventricular tachyarrhythmias in the hypokalaemic murine whole-heart model[1]. | [References]
[1] Robinson VM, et al. A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects. Br J Pharmacol. 2022 Jun;179(11):2713-2732. DOI:10.1111/bph.15775 |
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Lynnchem
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86-(0)29-85992781 17792393971 |
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Novachemistry
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https://www.novachemistry.com/ |
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cjbscvictory
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https://www.weikeqi-biotech.com/ |
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