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ChemicalBook--->CAS DataBase List--->946415-13-0

946415-13-0

946415-13-0 Structure

946415-13-0 Structure
IdentificationBack Directory
[Name]

Pamrevlumab
[CAS]

946415-13-0
[Synonyms]

Pamrevlumab
Pamrevlumab (anti-CTGF)
Research Grade Pamrevlumab
Research Grade Pamrevlumab(DHD82301)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].
[in vivo]

FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) in combination with Gemcitabine acutely decreases mouse pancreatic ductal adenocarcinoma (PDA) growth and induces neoplastic cell apoptosis in LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice[2].

[References]

[1] Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. DOI:10.1080/13543784.2020.1773790
[2] Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. DOI:10.1073/pnas.1300415110
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