| Identification | Back Directory | [Name]
Fe 200486 | [CAS]
934016-19-0 | [Synonyms]
Fe 200486
Reaxys ID: 26024935
Degarelix Acetate-d7
AUTFSFUMNFDPLH-KYMMNHPFSA-N
DEGARELIX (ACETATE);FE 200486
D-Alaninamide, N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-, acetate (1:1) | [Molecular Formula]
C84H107ClN18O18 | [MDL Number]
MFCD16879085 | [MOL File]
934016-19-0.mol | [Molecular Weight]
1692.34 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
Degarelix acetate (FE200486) is a gonadotropin-/luteinizing hormone-/follicle-stimulating hormone-releasing hormone (GnRHLHRHFSH-RH) receptor antagonist th at inhibits plasma testosterone for more than 40 days following a single s.c. dosage of 2 mg/kg in rats and monkeysshowing longer in vivo duration than abarelixganirelixcetrorelixazaline B or D-Trp6-LHRHand exhibiting only weak histamine-releasing potency in isolated r at mast cells. Bi-weekly s.c. dosing (2 mg/kg) is efficacious in suppressing the growth of human prostate cancer PAC120 xenograft-derived tumors in mice in vivo. |
|
| Company Name: |
Sumar biotech LLP
|
| Tel: |
+91-9898272121 +91-9898272121 |
| Website: |
www.sumarbiotech.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|