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ChemicalBook--->CAS DataBase List--->932359-76-7

932359-76-7

932359-76-7 Structure

932359-76-7 Structure
IdentificationBack Directory
[Name]

FiVe1
[CAS]

932359-76-7
[Synonyms]

FiVe1
8-Chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline
FiVe1 8-Chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline
[Molecular Formula]

C18H16Cl2N4
[MOL File]

932359-76-7.mol
[Molecular Weight]

359.25
Chemical PropertiesBack Directory
[Boiling point ]

570.2±60.0 °C(Predicted)
[density ]

1.374±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

5.56±0.10(Predicted)
[color ]

Light yellow to brown
Hazard InformationBack Directory
[Description]

FiVe1 is a novel vimentin (VIM) ligand, selectively and irreversibly inhibiting the growth of mesenchymally transformed breast cancer cells and soft tissue sarcomas of diverse histological subtypes.
[Uses]

FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor[1]. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness.?FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50:?267 nM); FOXC2-HMLER cells (IC50:?447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells[1].
[References]

[1] Michael J Bollong, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. DOI:10.1073/pnas.1716009114
Spectrum DetailBack Directory
[Spectrum Detail]

FiVe1(932359-76-7)1HNMR
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