| Identification | Back Directory | [Name]
Phen-DC3 Trifluoromethanesulfonate | [CAS]
929895-45-4 | [Synonyms]
Phen-DC3 Triflate
Phen-DC3 Trifluoromethanesulfonate | [Molecular Formula]
C36H26F6N6O8S2 | [MDL Number]
MFCD32067401 | [MOL File]
929895-45-4.mol | [Molecular Weight]
848.747 |
| Chemical Properties | Back Directory | [Melting point ]
>260 °C(Solv: ethyl ether (60-29-7)) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 34 mg/mL (40.06 mM) | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
PhenDC3 has been used:
- as a quadruplex (G4) ligand to study its effects on the binding of RNA quadruplex (rG4) to nucleolin (NCL)
- as a DNA/RNA G-quadruplexes (GQs) ligand to study its effects on the expression of double homeobox 4 (DUX4) gene
- as a G4 ligand to study its stability and selectivity towards pre-miR-92b rG4 complex and duplex DNA by fluorescence resonance energy transfer (FRET)-melting assay
| [Biological Activity]
Phen-DC3 Trifluoromethanesulfonate is a G4-specific ligand that inhibits the helicases FANCJ and DinG with IC50s of 65±6 and 50±10 nM, respectively. | [in vitro]
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remains fully stable in both PIF1-treated and WT cells. | [target]
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases) | [storage]
Store at -20°C |
|
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|