| Identification | Back Directory | [Name]
H-ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG-OH | [CAS]
92915-79-2 | [Synonyms]
OVA (323-339)
ISQAVHAAHAEINEAGR
H2N-ISQAVHAAHAEINEAGR-OH
OVALBUMIN CHICKEN (323-339)
OVA (323-339) (CHICKEN, JAPANESE QUAIL)
OVALBUMIN (323-339) (CHICKEN, JAPANESE QUAIL)
ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG
H-ILE-SER-GLN-ALA-VAL-HIS-ALA-ALA-HIS-ALA-GLU-ILE-ASN-GLU-ALA-GLY-ARG-OH
OvalbuMin (323-339) (chicken, japanese quail)
OVA (323-339) (chicken, japanese quail)
L-Arginine,L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-a-glutamyl-L-isoleucyl-L-asparaginyl-L-a-glutamyl-L-alanylglycyl-
L-Arginine, L-isoleucyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-histidyl-L-alanyl-L-alanyl-L-histidyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-asparaginyl-L-α-glutamyl-L-alanylglycyl- | [Molecular Formula]
C74H120N26O25 | [MDL Number]
MFCD02181011 | [MOL File]
92915-79-2.mol | [Molecular Weight]
1773.9 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
lyophilized powder | [pka]
3.33±0.10(Predicted) | [color ]
white | [Water Solubility ]
water, double-distilled: soluble |
| Hazard Information | Back Directory | [Uses]
Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice. | [General Description]
Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes. | [Biochem/physiol Actions]
With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein. | [in vivo]
OVA Peptide (323-339) represents a T and B cell epitope of OVA, which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice. Daily aerosolization of OVA Peptide (323-339) for 20 minutes over a period of 10 days has been as effective in the stimulation of a serum anti-OVA IgE antibody response as sensitization to native OVA by the same route. After sensitization to native OVA, the majority of the IgE anti-OVA response is directed against OVA Peptide (323-339). Evaluated by hematoxylin/eosin and major basic protein immunohistochemical stainings, OVA and OVA Peptide (323-339) induce similar lung inflammation. Interestingly, significant serum total IgE and OVA-specific IgE are observed in OVA mice when compared to saline control. OVA Peptide (323-339) mice show higher serum OVA-specific IgE, OVA Peptide (323-339)-specific IgE, IL-4 and lower IFN-γ similar to OVA mice. The proliferative response to OVA is found in cultured splenocytes of both OVA and OVA Peptide (323-339) mice, while the similar proliferative response to OVA Peptide (323-339) is only observed in the splenocytes of OVA Peptide (323-339)-sensitized and challenged mice. Although OVA Peptide (323-339) induces a Th2-like response in the mouse model as does OVA, OVA Peptide (323-339) has clearly limited immunogenic potency to activate OVA-sensitized and challenged mice splenocytes, unlike OVA[2]. |
|
|