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ChemicalBook--->CAS DataBase List--->919010-22-3

919010-22-3

919010-22-3 Structure

919010-22-3 Structure
IdentificationBack Directory
[Name]

9-(3-hydroxyphenyl)-8-phenyl-4,9-dihydrotetraazolo[1',5':1,2]pyrimido[4,5-d]pyridazin-5-ol
[CAS]

919010-22-3
[Synonyms]

Pfn1INC2
Pfn1-IN-C2
Pfn1 IN C2
Pfn1 inhibitor C2
9-(3-hydroxyphenyl)-8-phenyl-4,9-dihydrotetraazolo[1',5':1,2]pyrimido[4,5-d]pyridazin-5-ol
[Molecular Formula]

C18H13N7O2
[MOL File]

919010-22-3.mol
[Molecular Weight]

359.34
Chemical PropertiesBack Directory
[density ]

1.68±0.1 g/cm3(Predicted)
[pka]

9.08±0.60(Predicted)
Hazard InformationBack Directory
[Description]

Pfn1-IN-C2 is an inhibitor of Profilin1 (Pfn1). It has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.
[Uses]

Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC). Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro[1].
[References]

[1] Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction
919010-22-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Specs  
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Website: www.specs.net
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