| Identification | Back Directory | [Name]
PS372424 | [CAS]
914291-61-5 | [Synonyms]
PS372424
3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[(cyclohexylmethyl)amino]carbonyl]butyl]-2-(1,4-dioxo-4-phenylbutyl)-1,2,3,4-tetrahydro-, (3S)- | [Molecular Formula]
C33H44N6O4 | [MDL Number]
MFCD32174266 | [MOL File]
914291-61-5.mol | [Molecular Weight]
588.74 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.47±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation[1][2]. | [Biological Activity]
PS372424 is a highly specific agonist of human CXCR3 th at potently inhibits the migration of activated T cells toward the chemokine mixture in synovial fluid from patients with active rheumatoid arthritis. PS372424 activated ERK in T cells with a similar potency and kinetic to the natural ligand CXCL11. | [IC 50]
Human CXCR3 | [References]
[1] Boyé K, et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun. 2017 Nov 17;8(1):1571. DOI:10.1038/s41467-017-01686-y
[2] O'Boyle G, et al. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4598-603. DOI:10.1073/pnas.1118104109
[3] Stroke IL, et al. Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries. Biochem Biophys Res Commun. 2006 Oct 13;349(1):221-8. DOI:10.1016/j.bbrc.2006.08.019 |
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Merck KGaA
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MedChemExpress
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