| Identification | Back Directory | [Name]
(3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one | [CAS]
90828-16-3 | [Synonyms]
(Z)-SU4312
(Z)-SU-4312,(Z)SU4312,(Z) SU4312
(3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-, (3Z)- | [Molecular Formula]
C17H16N2O | [MDL Number]
MFCD00224096 | [MOL File]
90828-16-3.mol | [Molecular Weight]
264.32 |
| Hazard Information | Back Directory | [Uses]
cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier[1]. | [References]
[1] Wei Cui, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14. DOI:10.1111/bph.12004 |
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