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ChemicalBook--->CAS DataBase List--->908027-21-4

908027-21-4

908027-21-4 Structure

908027-21-4 Structure
IdentificationBack Directory
[Name]

MI 63
[CAS]

908027-21-4
[Synonyms]

MI 63
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
[Molecular Formula]

C29H35Cl2FN4O3
[MOL File]

908027-21-4.mol
[Molecular Weight]

577.52
Chemical PropertiesBack Directory
[Boiling point ]

732.3±60.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[pka]

12.04±0.70(Predicted)
Hazard InformationBack Directory
[Description]

MI-63 is a potent, specific, non-peptide inhibitor of the MDM2-p53 interaction.
[Uses]

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].
[Definition]

ChEBI: MI-63 is an azaspiro compound resulting from the formal fusion of position 3 of 6-chloro-oxindole with position 3 of (2R,3SS5S)-3-(3-chloro-2-fluorophenyl)-5-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]pyrrolidine-2-carboxamide. It is a potent inhibitor of the MDM2-p53 interaction. It has a role as an apoptosis inducer. It is an azaspiro compound, a member of morpholines, a member of oxindoles, a member of pyrrolidines, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide.
[References]

[1] Canner JA, et al., MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009 Sep 1;101(5):774-81. DOI:10.1038/sj.bjc.6605199
908027-21-4 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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