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ChemicalBook--->CAS DataBase List--->906669-07-6

906669-07-6

906669-07-6 Structure

906669-07-6 Structure
IdentificationBack Directory
[Name]

KPLH1130
[CAS]

906669-07-6
[Synonyms]

KPLH1130
3H-1,2,4-Triazol-3-one, 5-(2,4-dihydroxyphenyl)-2,4-dihydro-4-(4-methylphenyl)-
KPLH 1130,Pyruvate dehydrogenase kinase,PDH kinase,KPLH-1130,inhibit,Inhibitor,KPLH1130,PDHK
[Molecular Formula]

C15H13N3O3
[MDL Number]

MFCD32067959
[MOL File]

906669-07-6.mol
[Molecular Weight]

283.28
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to gray
Hazard InformationBack Directory
[Uses]

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice[1].
[References]

[1] Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944. DOI:10.3389/fimmu.2019.00944
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