| Identification | Back Directory | [Name]
2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3S,4S)- | [CAS]
905854-03-7 | [Synonyms]
(3S,4S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3S,4S)- | [Molecular Formula]
C23H19N3O2 | [MDL Number]
MFCD11977596 | [MOL File]
905854-03-7.mol | [Molecular Weight]
369.42 |
| Chemical Properties | Back Directory | [Boiling point ]
715.9±60.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.28±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC)[1]. | [References]
[1] Remsing Rix LL, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9(2):353-8. DOI:10.1021/cb400660a |
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A.J Chemicals
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91-9810153283 |
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www.ajchemicals.com |
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