| Identification | Back Directory | [Name]
HEPARINASE | [CAS]
9025-39-2 | [Synonyms]
EC 4.2.2.7
Neutralase
HEPARINASE
HEPARINASE I
Lyase, heparin
HEPARIN LYASE I
Heparinase I - 0.1 IU
Heparin lyaseI, Heparinase
Native Flavobacterium heparinum Heparinase I
Heparinase I from Bacteroides eggerthii, Recombinant
Heparinase I from Flavobacterium heparinum, Recombinant
Heparin lyase from Bacteroides thetaiotaomicron, Recombinant
HeparinaseI from Flavobacterium heparinum,Heparin lyaseI, Heparinase | [Molecular Formula]
NULL | [MDL Number]
MFCD00131317 |
| Hazard Information | Back Directory | [Uses]
Heparinase I from Flavobacterium heparinum has been used:
- in the digestion of plasma samples
- to study the effect of medium, washing and sonication on the infectivity of Chlamydia pneumonia
- in enzymatic removal of heparan sulfate from the surface of human rhabdomyosarcoma cells
| [Biochem/physiol Actions]
Heparinase I from Flavobacterium heparinum acts by cleaving the α-glycoside linkage at AT III binding site in heparin. This results in small oligosaccharide fragments and heparinase I neutralizes the protein′s action of anticoagulation. Therefore it might replace the use of protamine in reversing heparin induced anticoagulation after coronary artery bypass surgery. Heparinase I possesses a half-life of 15-18 minutes. |
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