| Identification | Back Directory | [Name]
EC 3.5.1.11 | [CAS]
9014-06-6 | [Synonyms]
E-PCA
Semacylase
EC 3.5.1.11
Einecs 232-753-8
E-PCA USP/EP/BP
PENICILLIN ACYLASE
PENICILLIN AMIDASE
penicillin acyclase
beta-Lactam acylase
Penicillin V amidase
PENICILLIN G AMIDASE
EC 3.5.1.11 USP/EP/BP
PENICILLIN AMIDOHYDROLASE
IMMOBILIZED ACYLASE ENZYME
Penicillin Amidase from E.Coli
penicillin amidase from E. coli
Immobilized Penicillin G Acylase
PENICILLIN G AMIDASE, IMMOBILIZED
E-PCA, Penicillin amidohydrolase
PENICILLIN G AMIDASE, CARRIER-FIXED
Penicillinamidaseimm.oneupergitce.coli
penicillin amidase from escherichia coli
alpha-Acylamino-beta-lactam acylhydrolase
Penicillin Amidase from Bacillus megaterium
Penicillin Acylase, Penicillin Amidohydrolase
PENICILLIN AMIDASE, IMMOBILIZED ON EUPERGIT(R) C
Penicillin Amidase solution from Escherichia coli
Penicillin G Amidase, ammonium sulfate suspension
Penicillin G Amidase, immobilized from E. coli
PENICILLIN AMIDASE IMM. ON EUPERGIT C E. COLI, 100 U G
Penicillin Amidase-Acrylic beads from Escherichia coli
Penicillin Amidase, immobilized on Eupergit? C from E. coli
Penicillin Amidase, immobilized on Eupergit(R) C from E. coli | [EINECS(EC#)]
232-753-8 | [MDL Number]
MFCD00147869 |
| Chemical Properties | Back Directory | [density ]
1.37[at 20℃] | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
2-8°C | [form ]
lyophilized powder | [color ]
White to light brown | [biological source]
Escherichia coli | [Specific Activity]
5-10units/mg protein |
| Hazard Information | Back Directory | [Uses]
Penicillin amidase was used to study its effect in release of fatty acid and HSL (homoserine lactone) from AHLs (N -acylhomoserine lactones) in degradation of antibiotics. It was used as positive control for assaying penicillin G acylase activity in the study of functional analysis of bile salt hydrolase and penicillin acylase family members in Lactobacillus sp. Penicillin amidase may be used for synthesis of 6-aminopenicillanic acid from penicillin-G and for the industrial production of β-lactam antibiotics. | [General Description]
Penicillin amidase is a periplasmic 80K heterodimer with A and B chains (209 and 566 amino acids, respectively). It is widely distributed among microorganisms, including bacteria, yeast and filamentous fungi. Among all the sources, the enzyme produced by E. coli is most well-characterized and common for industrial application. | [Biochem/physiol Actions]
The biosynthesis of Penicillin amidase in E. coli by hydrophobic protein chromatography is an inducible reaction which is regulated by metabolized carbon source (e.g. polyols, carboxylic acid etc.). It is also influenced by catabolite repression. It catalyzes the formation of amide bonds through an acyl-enzyme intermediate. |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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