| Identification | Back Directory | [Name]
Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]- | [CAS]
898562-94-2 | [Synonyms]
MP 10
EOS-61169
PF-2545920(MP-10)
MP 10, Mardepodect
PF 2545920; PF2545920;MP10;MP 10
PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, MARDEPODECT
2-({4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
2-[(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl]quinoline
Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline trihydrochloride | [Molecular Formula]
C25H20N4O | [MOL File]
898562-94-2.mol | [Molecular Weight]
392.45 |
| Chemical Properties | Back Directory | [Melting point ]
180-181 °C | [Boiling point ]
568.6±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.05 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.5 mg/ml | [form ]
A crystalline solid | [pka]
4.32±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMPand is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntingtonμs disease. | [storage]
Store at -20°C |
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