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ChemicalBook--->CAS DataBase List--->897109-93-2

897109-93-2

897109-93-2 Structure

897109-93-2 Structure
IdentificationBack Directory
[Name]

F7H
[CAS]

897109-93-2
[Synonyms]

F7H
F7H inhibitor
4-Fluoro-N-(4-((2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)thio)phenyl)benzamide
[Molecular Formula]

C24H18FN3O2S2
[MOL File]

897109-93-2.mol
[Molecular Weight]

463.55
Chemical PropertiesBack Directory
[density ]

1.416±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

9.156±0.50(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD)[1].
[References]

[1] Li C, et al. Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7. J Med Chem. 2023 Sep 14;66(17):11855-11868.. . DOI:10.1021/acs.jmedchem.2c01795
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