| Identification | Back Directory | [Name]
2-cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione | [CAS]
883958-36-9 | [Synonyms]
2-cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione | [Molecular Formula]
C24H23N3O2 | [MDL Number]
MFCD06591800 | [MOL File]
883958-36-9.mol | [Molecular Weight]
385.46 |
| Chemical Properties | Back Directory | [Boiling point ]
520.1±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
2.56±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MLS1082 is a positive allosteric modulator of the D1 dopamine receptor which acts at diverse binding sites. | [Uses]
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling[1]. | [IC 50]
D1 Receptor | [References]
[1] Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696. DOI:10.1016/j.bmcl.2020.127696
[2] Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. DOI:10.1124/mol.118.113175 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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