| Identification | Back Directory | [Name]
netzahualcoyone | [CAS]
87686-36-0 | [Synonyms]
netzahualcoyone
3,21β-Dihydroxy-15-methyl-2,22-dioxo-24,26-dinor-D:A-friedoolean-1(10),3,5,7,14-penten-29-oic acid methyl ester | [Molecular Formula]
C30H36O6 | [MOL File]
87686-36-0.mol | [Molecular Weight]
492.603 |
| Hazard Information | Back Directory | [Description]
Netzahualcoyone, the activity of netzahualcoyone on Bacillus subtilis and Escherichia coli was studied. The product inhibited the respiration of intact cells of B. subtilis but had no effect on the respiration of E. coli. However, when preparations of sonically disrupted cells were examined, inhibitory activity on both bacteria was observed. | [Uses]
Netzahualcoyone is a triterpenoid compound isolated from the Celastraceae plant family. Netzahualcoyone exhibits broad-spectrum antibiotic activity against Gram-positive bacteria and yeasts, but is not active against Gram-negative bacteria. Netzahualcoyone can be utilized in the development of antibiotics and for studying antimicrobial mechanisms[1]. | [References]
[1] Moujir L, et al. Mode of action of netzahualcoyone[J]. Antimicrobial agents and chemotherapy, 1991, 35(1): 211-213. DOI:10.1128/AAC.35.1.211 |
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