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Isamoltane Hemifumarate is an analog of isamoltane (CGP 361A0, which is a beta-adrenoceptor ligand that has anxiolytic activity. | [in vivo]
Isamoltane (0.3-30 mg/kg; i.p) does not alter the accumulation of 5-HTP in the rat hippocampus, and increases 5-HT synthesis in cortical tissue. Isamoltane reduces 5-HTP accumulation in the striatum[1]. | Animal Model: | Male Sprague-Dawley rats (200-300 g)[1] | | Dosage: | 0.3, 1, 3, 10, 30 mg/kg | | Administration: | I.p. | | Result: | 38% reduction of 5-HTP accumulation was found with 30 mg/ kg in the striatum.
Did not alter the accumulation of 5-HTP in the hippocampus.
Increased 5-HT synthesis at 0.3, 1 and 3 mg/kg in cortical tissue.
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| [IC 50]
β-adrenoceptor: 8.4 nM (IC50); 5-HT1B Receptor: 39 nM (IC50) | [storage]
Store at -20°C |
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