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ChemicalBook--->CAS DataBase List--->870603-16-0

870603-16-0

870603-16-0 Structure

870603-16-0 Structure
IdentificationBack Directory
[Name]

BMS-908662
[CAS]

870603-16-0
[Synonyms]

BMS-908662
BMS-908662(1X-281)
Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
[Molecular Formula]

C24H19ClN4O4
[MOL File]

870603-16-0.mol
[Molecular Weight]

462.89
Chemical PropertiesBack Directory
[density ]

1.526±0.06 g/cm3(Predicted)
[pka]

10.77±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].
[IC 50]

c-Raf: 2.6 nM (IC50); B-Raf: 4.5 nM (IC50); B-RafV600E: 6 nM (IC50)
[References]

[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5
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