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ChemicalBook--->CAS DataBase List--->869988-94-3

869988-94-3

869988-94-3 Structure

869988-94-3 Structure
IdentificationBack Directory
[Name]

TLQP 21
[CAS]

869988-94-3
[Synonyms]

TLQP 21
TLQP-21 (Mouse, rat)
H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH
L-Arginine, L-threonyl-L-leucyl-L-glutaminyl-L-prolyl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-histidyl-L-phenylalanyl-L-histidyl-L-histidyl-L-alanyl-L-leucyl-L-prolyl-L-prolyl-L-alanyl-
[Molecular Formula]

C107H170N40O26
[MDL Number]

MFCD11045147
[MOL File]

869988-94-3.mol
[Molecular Weight]

2432.75
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at -20°C
[Water Solubility ]

Soluble to 1 mg/ml in Water
Hazard InformationBack Directory
[Uses]

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2].
[storage]

Store at -20°C
[References]

[1] Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130. DOI:10.3390/ijms21010130
[2] Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753. DOI:10.1016/j.str.2014.10.001
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