| Identification | Back Directory | [Name]
TLQP 21 | [CAS]
869988-94-3 | [Synonyms]
TLQP 21
TLQP-21 (Mouse, rat)
H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH
L-Arginine, L-threonyl-L-leucyl-L-glutaminyl-L-prolyl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-histidyl-L-phenylalanyl-L-histidyl-L-histidyl-L-alanyl-L-leucyl-L-prolyl-L-prolyl-L-alanyl- | [Molecular Formula]
C107H170N40O26 | [MDL Number]
MFCD11045147 | [MOL File]
869988-94-3.mol | [Molecular Weight]
2432.75 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [Water Solubility ]
Soluble to 1 mg/ml in Water | [Sequence]
Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg |
| Hazard Information | Back Directory | [Uses]
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions[1][2]. | [storage]
Store at -20°C | [References]
[1] Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130. DOI:10.3390/ijms21010130
[2] Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753. DOI:10.1016/j.str.2014.10.001 |
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