| Identification | Back Directory | [Name]
FMoc-Val-Cit-PAB-PNP | [CAS]
863971-53-3 | [Synonyms]
Moc-Val-Cit-PAB-PNP
FMoc-Val-Cit-PAB-PNP
Fmoc-Val-Cit-PAB-PNP, >95%
FMOC-VAL-CIT-PAB-PNP (9-FLUORENYLMETHYLOXYCARBONYL-VALYL-CITRULLYL-(4-AMINOBENZYL)-(4-NITROPHENYL)CARBONATE)
L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
{4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl 4-nitrophenyl carbonate
4-[[(2S)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
(9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate | [Molecular Formula]
C40H42N6O10 | [MDL Number]
MFCD22200278 | [MOL File]
863971-53-3.mol | [Molecular Weight]
766.8 |
| Chemical Properties | Back Directory | [Melting point ]
189 °C(dec.) | [Boiling point ]
1024.0±65.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
powder to crystal | [pka]
10.63±0.46(Predicted) | [color ]
White to Light yellow | [Sequence]
Fmoc-Val-Cit-PAB-PNP |
| Hazard Information | Back Directory | [Description]
Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload. | [Biological Activity]
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). |
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