| Identification | Back Directory | [Name]
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) | [CAS]
852391-15-2 | [Synonyms]
Nec-1s
CS-2815
Nec-1s(7-Cl-O-Nec1)
Necrostatin-2 raceMate
Necrostatin 2 (raceMate)
RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl- | [Molecular Formula]
C13H12ClN3O2 | [MDL Number]
MFCD19443135 | [MOL File]
852391-15-2.mol | [Molecular Weight]
277.706 |
| Chemical Properties | Back Directory | [Melting point ]
173-175℃ | [density ]
1.450±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
Off-white to pale yellow solid | [pka]
8.48±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5 | [Uses]
Necrostatin 1s is an inhibitor of indolamine 2,3-deoxygenase. Necrostatin 1s is a neuroprotective with potential therapeutic functions against brain ischemia. | [storage]
Store at -20°C | [References]
1) Degterev?et al. (2005)?Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?1?112
2) Teng?et al. (2005)?Structure-activity relationship of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett.,?15?5039
3) Degterev?et al. (2012)?Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase; Cell Death Differ.,?20?366
4) Takahashi?et al. (2012)?Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models; Cell Death Dis.,?3?e437
5) Degterev?et al. (2013)?Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury; Nat. Chem. Biol.,?9?192 |
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ChemShuttle, Inc.
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0510-83588313-811 18800520310; |
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https://www.jiehuapharma.com/ |
| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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