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ChemicalBook--->CAS DataBase List--->851881-59-9

851881-59-9

851881-59-9 Structure

851881-59-9 Structure
IdentificationBack Directory
[Name]

(R)-ADX-47273
[CAS]

851881-59-9
[Synonyms]

(R)-ADX-47273
Inhibitor,inhibit,mGluR,(R)ADX47273,(R) ADX 47273,Metabotropic glutamate receptors
(4-Fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone
Methanone, (4-fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-
[Molecular Formula]

C20H17F2N3O2
[MOL File]

851881-59-9.mol
[Molecular Weight]

369.36
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . mGluR5|168 nM (EC50)

(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].

[Uses]

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
[IC 50]

mGlu5: 168 nM (EC50)
[References]

[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.

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