| Identification | Back Directory | [Name]
phenanthridin-6-amine | [CAS]
832-68-8 | [Synonyms]
6-Phenanthridinamine
phenanthridin-6-amine
6-Aminophenanthridine
6-Amino-phenanthridine
Phenanthridine-6-amine
6-Aminophenanthridine >=98% (HPLC)
6Aminophenanthridine,6 Aminophenanthridine | [Molecular Formula]
C13H10N2 | [MDL Number]
MFCD01708752 | [MOL File]
832-68-8.mol | [Molecular Weight]
194.23 |
| Chemical Properties | Back Directory | [Melting point ]
194-195 °C(Solv: benzene (71-43-2)) | [Boiling point ]
406.4±20.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
6.88±0.10(Predicted) | [color ]
white to brown |
| Hazard Information | Back Directory | [Uses]
6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1]. | [Biological Activity]
6-Aminophenanthridine selectively inhibits protein folding activity of the ribosome (PFAR). Apparently 6-Aminophenanthridine interacts with the ribosome domain V rRNA and the protein substrate. 6-Aminophenanthridine is an antiprion compound th at promotes mammalian prion clearance. | [storage]
Store at -20°C | [References]
[1] Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288(26):19081-19089. DOI:10.1074/jbc.M113.466748 |
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