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ChemicalBook--->CAS DataBase List--->83027-13-8

83027-13-8

83027-13-8 Structure

83027-13-8 Structure
IdentificationBack Directory
[Name]

AMN082 DIHYDROCHLORIDE
[CAS]

83027-13-8
[Synonyms]

AMN 082
AMN082 free base
AMN 082 dihydrochlor
AMN082 DIHYDROCHLORIDE
N,N'-bis(diphenylMethyl)ethylenediaMine
N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE
N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride
N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE
[Molecular Formula]

C28H28N2
[MDL Number]

MFCD08702723
[MOL File]

83027-13-8.mol
[Molecular Weight]

392.54
Chemical PropertiesBack Directory
[Melting point ]

105.5 °C
[Boiling point ]

533.7±45.0 °C(Predicted)
[density ]

1.086±0.06 g/cm3(Predicted)
[storage temp. ]

Desiccate at +4°C
[solubility ]

DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[pka]

8.38±0.29(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

AMN082 dihydrochloride is a selective agonist at mGluR-7.
[Definition]

ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).
[Biological Activity]

The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
Spectrum DetailBack Directory
[Spectrum Detail]

AMN082 DIHYDROCHLORIDE(83027-13-8)1HNMR
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