| Identification | Back Directory | [Name]
Sulconazle Nitrate | [CAS]
82382-23-8 | [Synonyms]
Sulcozle Nitrate
Sulconazle Nitrate
SULCONAZOLE NITRATE
(±)-Sulconazole nitrat
Sulconazle Nitrate USP/EP/BP
SULCONAZOLE NITRATE FPC(CRM STANDARD) USP/EP/BP
1-[2-(4-Chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C18H15Cl3N2S.HNO3 | [MOL File]
82382-23-8.mol | [Molecular Weight]
460.76 |
| Chemical Properties | Back Directory | [Melting point ]
148-153°C | [storage temp. ]
Refrigerator | [solubility ]
Acetonitrile (Slightly, Heated), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [CAS DataBase Reference]
82382-23-8 |
| Hazard Information | Back Directory | [Description]
Sulconazole nitrate is an imidazole antifungal agent closely related to econazole.
It is effective in the topical treatment of a broad spectrum of superficial fungal
infections. | [Originator]
Syntex (USA) | [Uses]
Antifungal. | [Definition]
ChEBI:Sulconazole nitrate is an organic nitrate salt, a conazole antifungal drug and an imidazole antifungal drug. | [Brand name]
Exelderm (Westwood-Squibb). | [Biological Activity]
Sulconazole Nitrate is an imidazole derivative with broad-spectrum antifungal activity. | [Clinical Use]
1-[2,4-Dichloro-β-[p-chlorobenzyl)thio]phenethyl]imidazolemononitrate (Exelderm) is the white crystalline nitricacid salt of sulconazole. It is sparingly soluble in water butsoluble in ethanol. The salt is used in a solution and a cream in 1% concentration for the treatment of local tinea infections,such as jock itch, athlete’s foot, and ringworm. | [in vitro]
Sulconazole Nitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L. | [in vivo]
The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis. |
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