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ChemicalBook--->CAS DataBase List--->79944-56-2

79944-56-2

79944-56-2 Structure

79944-56-2 Structure
IdentificationBack Directory
[Name]

IDAZOXAN HYDROCHLORIDE
[CAS]

79944-56-2
[Synonyms]

RX 781094A
IdazoxanHCl
IDAZOXAN HYDROCHLORIDE
(+/-)-Idazoxan Monohydrochloride
2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
[Molecular Formula]

C11H13ClN2O2
[MDL Number]

MFCD00069293
[MOL File]

79944-56-2.mol
[Molecular Weight]

240.69
Chemical PropertiesBack Directory
[Melting point ]

207-208°
[storage temp. ]

Store at RT
[solubility ]

H2O: 300 mg/mL
[form ]

Powder
[color ]

White to off-white
[Water Solubility ]

Soluble to 100 mM in water
[Stability:]

Hygroscopic
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[Safety Statements ]

7
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
Hazard InformationBack Directory
[Chemical Properties]

mp 207-209°C
[Uses]

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
[Uses]

Antiparkinsonian;Alpha2 agonist
[Biological Activity]

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
[Biochem/physiol Actions]

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
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