| Identification | Back Directory | [Name]
WAY-638774 | [CAS]
796092-26-7 | [Synonyms]
WAY-638774
1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-4-((3-fluorophenyl)sulfonyl)piperazine
Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(3-fluorophenyl)sulfonyl]- | [Molecular Formula]
C18H19FN2O6S2 | [MOL File]
796092-26-7.mol | [Molecular Weight]
442.48 |
| Chemical Properties | Back Directory | [Boiling point ]
616.7±65.0 °C(Predicted) | [density ]
1.493±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-7.65±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 μM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells[1]. | [References]
[1] Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53(3):1048-55. DOI:10.1021/jm901577g |
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