790186-68-4

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790186-68-4 Structure

Identification	Back Directory
[Name] GW284543
[CAS] 790186-68-4
[Synonyms] GW284543 UNC10225170 GW284543 (UNC10225170) 4-Quinolinamine, 6,7-dimethoxy-N-(3-phenoxyphenyl)-
[Molecular Formula] C23H20N2O3
[MDL Number] MFCD32067894
[MOL File] 790186-68-4.mol
[Molecular Weight] 372.42

Chemical Properties	Back Directory
[storage temp. ] Keep in dark place,Sealed in dry,Room Temperature
[solubility ] DMSO:67.0(Max Conc. mg/mL);179.9(Max Conc. mM)
[form ] Solid
[color ] Off-white to gray

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Information	Back Directory
[Uses] GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
[IC 50] MEK5
[References] [1] Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. DOI:10.1016/j.ccell.2018.10.001

Spectrum Detail	Back Directory
[Spectrum Detail] GW284543(790186-68-4)¹HNMR

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