| Identification | Back Directory | [Name]
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide | [CAS]
7497-07-6 | [Synonyms]
CS-1114
NSC 405020
NSC 405020, >=98%
NSC 405020, 7497-07-6
NSC 405020;NSC-405020
NSC405020, 98%, MT1-MMP inhibitor
3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
Benzamide, 3,4-dichloro-N-(1-methylbutyl)-
3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020
NSC 405020 3,4-Dichloro-N-(1-methylbutyl)-benzamide | [EINECS(EC#)]
804-136-9 | [Molecular Formula]
C12H15Cl2NO | [MDL Number]
MFCD02006898 | [MOL File]
7497-07-6.mol | [Molecular Weight]
260.16 |
| Chemical Properties | Back Directory | [Boiling point ]
353.7±32.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). | [form ]
powder | [pka]
13.38±0.46(Predicted) | [color ]
white to beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3 | [Uses]
NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP. | [storage]
Store at RT | [References]
1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339
2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167
3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945 |
|
|