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ChemicalBook--->CAS DataBase List--->725247-18-7

725247-18-7

725247-18-7 Structure

725247-18-7 Structure
IdentificationBack Directory
[Name]

XCT 790
[CAS]

725247-18-7
[Synonyms]

CS-1881
XCT 790; XCT-790
3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-
(E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide XCT 790
XCT 790 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide
[Molecular Formula]

C23H13F9N4O3S
[MDL Number]

MFCD08277031
[MOL File]

725247-18-7.mol
[Molecular Weight]

596.42
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≥10mg/mL
[form ]

solid
[color ]

yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H413
[Precautionary statements ]

P264-P270-P273-P301+P312-P330
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .
[Uses]

XCT790 is a potent inverse agonist of ERRα.
[Definition]

ChEBI: XCT 790 is a member of cinnamamides.
[Biochem/physiol Actions]

XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).
[storage]

Store at +4°C
[References]

[1] lu x, peng l, lv m, ding k. recent advance in the design of small molecular modulators of estrogen-related receptors. curr pharm des. 2012;18(23):3421-31.
[2] wu f, wang j, wang y, kwok tt, kong sk, wong c. estrogen-related receptor alpha (erralpha) inverse agonist xct-790 induces cell death in chemotherapeutic resistant cancer cells. chem biol interact. 2009 oct 7;181(2):236-42.
Spectrum DetailBack Directory
[Spectrum Detail]

XCT 790(725247-18-7)1HNMR
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