| Identification | Back Directory | [Name]
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine | [CAS]
722515-03-9 | [Synonyms]
2’-Chloro-N6-(4-trifluoromethyl)benzyladenosine
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine
Adenosine, 2-chloro-N-[[4-(trifluoromethyl)phenyl]methyl]- (9CI) | [Molecular Formula]
C18H17ClF3N5O4 | [MOL File]
722515-03-9.mol | [Molecular Weight]
459.81 |
| Hazard Information | Back Directory | [Uses]
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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