| Identification | Back Directory | [Name]
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione | [CAS]
69431-87-4 | [Synonyms]
AM2947
AM-2947
AM 2947
A-39183B
Setomimycin
Antibiotic A-39183B
SetoMiMycin [SetoMiMicin]
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione | [Molecular Formula]
C34H28O9 | [MDL Number]
MFCD01939963 | [MOL File]
69431-87-4.mol | [Molecular Weight]
580.58 |
| Chemical Properties | Back Directory | [Boiling point ]
765.2±60.0 °C(Predicted) | [density ]
1.479±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: soluble; DMSO: soluble | [form ]
A solid | [pka]
3.61±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Setomimycin is a rare 9,9’-bianthryl antibiotic first isolated from a strain of Streptomyces pseudovenezuelae by Omura and colleagues at the Kitasato Institute, Japan, in 1978. Setomimycin is active against Gram positive bacteria, including mycobacteria, and has antitumor activity both in vitro and in vivo. Limited access has restricted further research on this metabolite. | [Uses]
Setomimycin is an antibiotic that is active against Gram positive bacteria, including mycobacteria. | [in vivo]
Setomimycin (20 mg/kg; i.p.; alternate days for two weeks) shows antitumor activity in mice[2].
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].
| Pharmacokinetic parameters | Value | | Cmax (ng/ml) | 694 ± 62 | | Tmax (h) | 0.3 ± 0.1 | | T1/2 (h) | 2.3 ± 0.5 | | AUC0-t (ng.h/mL) | 2613 ± 111 | | AUC0-α (ng.h/mL) | 2734 ± 108 | | Vd (L/Kg) | 24 ± 4 | | Cl (L/h/Kg) | 7.4 ± 0.3 |
Female BALB/c mice, 20 mg/kg ip (1 % DMSO +30 % PEG-200 + 2 % Tween 80 + q.s. water (v/v)) [2]| Animal Model: | 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2] | | Dosage: | 20 mg/kg | | Administration: | I.p.; every other day for two weeks | | Result: | Decreased primary tumor weight (76%) and volume (90.5%). |
| [storage]
Store at -20°C |
|
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