| Identification | Back Directory | [Name]
Benzo[b]thiophene-2-carboxamide, N-[2-(aminocarbonyl)phenyl]-5-nitro- | [CAS]
690693-02-8 | [Synonyms]
G 43|||G-43
Benzo[b]thiophene-2-carboxamide, N-[2-(aminocarbonyl)phenyl]-5-nitro- | [Molecular Formula]
C16H11N3O4S | [MOL File]
690693-02-8.mol | [Molecular Weight]
341.34 |
| Chemical Properties | Back Directory | [Boiling point ]
516.4±40.0 °C(Predicted) | [density ]
1.534±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.60±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study[1][2]. | [in vivo]
G43 (100?μM twice daily for 4 weeks, topically administration) reduces S. mutans virulence in vivo[1]. | Animal Model: | The rat model of dental caries infected with S. mutans UA159[1] | | Dosage: | 100?μM twice daily for 4 weeks | | Administration: | Topically administration | | Result: | Reduced the buccal, sulcal, and proximal surface caries scores, but did not lose weight over the course of the study. |
| [References]
[1] Zhang Q, et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017;7(1):5974. DOI:10.1038/s41598-017-06168-1
[2] Scaffa PMC, et al. The potential use of glycosyl-transferase inhibitors for targeted reduction of S. mutans biofilms in dental materials. Sci Rep. 2023;13(1):11889. DOI:10.1038/s41598-023-39125-2 |
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